ea0065p224 | Metabolism and Obesity | SFEBES2019
Pizza Grazia
, Cheung Rebecca
, Rolando Delphine
, Nguyen-Tu Marie-Sophie
, Cebola Ines
, Chabosseau Pauline
, Marchetti Piero
, Shapiro James
, Piemonti Lorenzo
, Sakamoto Kei
, Smith David M
, Rutter Guy A
, Martinez-Sanchez Aida
MicroRNAs (miRNAs) are small non-coding RNAs that repress protein production post-transcriptionally. MiRNAs play crucial roles in metabolism, endocrine cells development and in processes altered in T2D, such as insulin secretion. MiR-125b controls proliferation, apoptosis and differentiation of various cell types, although its role in β-cells remains unclear. Recent studies show an association between high levels of circulating miR-125b and hyperglycaemia (HbA1c) in predi...